Cathepsin B Inhibitor III
[L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Colorless or white solid. An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531). Purity: ≥98% by HPLC. Ref.: Chan, V.J., et al. 1999. Biochem. J. 340, 113. Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187. Yamamoto, A., et al. 1997. J. Biochem. 121, 974. Inubushi, T., et al. 1994. J. Biochem. 116, 282. Murata, M., et al. 1991. FEBS Lett. 280, 307. Towatari, T., et al. 1991. FEBS Lett. 280, 311. |
