Cathepsin B Inhibitor IV [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester White solid. A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. Purity: ≥98% by HPLC. Ref.: Sever, N., et al. 2002. Biol. Chem. 383, 839. Authier, F., et al. 1999. J. Biol. Chem. 274, 33723. Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118. Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377. |