3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

White solid. Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca²⁺ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells. Purity: ≥99% by titration (dry basis). Contaminants: heavy metals: ≤10 ppm. Heavy metals: ≤10 ppm. RTECS EV6475000, CAS 58-08-2.

Merck Index: 14, 1636
Ref.: Zhen, W., and Vaugha, A. T. 1995. Radiat. Res. 141, 170. Howell, L. L. 1993. Cancer Res. 54, 4993. Traganos, F., et al. 1993. Cancer Res. 53, 4613. Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.
R: 22;