Calpain Inhibitor II Off-white solid. Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome. Purity: >95% by HPLC. CAS 110115-07-6. N-Acetyl-Leu-Leu-Met Ref.: Ravid, T., et al. 2000. J. Biol. Chem. 275, 35840. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Sarin, A., et al. 1994. J. Immunol. 153, 862. Sarin, A., et al. 1993. J. Exp. Med. 178, 1693. Banik, N.L., et al. 1992. Neurochem. Res. 17, 797. Koohmaraie, M. 1992. Biochemie 74, 239. Pinter, M., et al. 1992. Biochemistry 31, 8201. Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24. Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195. |
