Carbobenzoxy-valinyl-phenylalaninal
MDL 28170 White lyophilized solid. A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity. Purity: ≥95% by HPLC. CAS 88191-84-8. Z-Val-Phe-CHO Ref.: Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663. Rami, A., et al. 1997. Neurosci. Res. 27, 93. Yamazaki, T., et al. 1997. Biochemistry 36, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Chard, P.S., et al. 1995. Neuroscience 65, 1099. Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474. |
