Calmodulin antagonist
CaM kinase II 290-309 White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate. Purity: ≥95% by HPLC. Sold on the basis of peptide content. CAS 115044-69-4. H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH Ref.: James, P., et al. 1995. Trends Biochem. Sci. 20, 38. Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062. Yazawa, M., et al. 1992. Biochemistry 31, 3171. Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190. |
