Z-L-Abu-CONH(CH2)3-morpholine Off-white solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice. Purity: ≥95% by HPLC. Z-Leu-Abu-CONH(CH2)3-morpholine (Abu = a-aminobutyric acid) Ref.: Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191. DeBiasi, R.L., et al. 2001. J. Virol. 75, 351. Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66. Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426. Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046. James, T., et al. 1998. J. Neurosci. Res. 51, 218. Li, Z., et al. 1996. J. Med. Chem. 39, 4089. Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428. Bartus, R.T., et al. 1995. Neurol. Res. 17, 249. Bartus, R.T., et al. 1994. Stroke 25, 2265. |
