Z-L-Nva-CONH-CH2-2-Py Faint yellowish glassy semi-solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable dipeptidyl a-ketoamide compound that acts as a potent, selective, reversible, and active site inhibitor of calpain-1 (Ki = 19 nM). Shown to inhibit calpain-2 (Ki = 120 nM) and cathepsin-B(Ki = 750 nM) at higher concentrations. Purity: ≥90% by HPLC. Z-Leu-Nva-CONH-CH2-2-Pyridyl Ref.: Lokuta, M.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4006. Li, Z., et al. 1996. J. Med. Chem. 39, 4089. |
