N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal
SJA6017 White lyophilized solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable, reversible inhibitor of calpain (IC50 = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and a-spectrin in cultured lenses. Purity: ≥95% by HPLC. 4-Fluorophenylsulfonyl-Val-Leu-CHO Ref.: Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.
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