Off-white solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent g-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Purity: ≥98% by HPLC. CAS 101932-71-2. Ref.: Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
R: 23/24/25-38; S: 26-36/37/39-45 |
