CS Peptide White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Ce (PKCe) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH). Purity: ≥95% by HPLC. Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2 Ref.: Eto, A., et al. 1995. J. Biol. Chem. 270, 25115. Kawasaki, J., et al. 1989. J. Biochem. 106, 274. Maki, M., et al. 1989. J. Biol. Chem. 264, 18866. |
