KRPPKLGQIGRAKRVVIEDDRIDDVLK-OH Off-white solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN. Purity: ≥95% by HPLC. H-Lys-Arg-Pro-Pro-Lys-Leu-Gly-Gln-Ile-Gly-Arg-Ala-Lys-Arg-Val-Val-Ile-Glu-Asp-Asp-Arg-Ile-Asp-Asp-Val-Leu-Lys-OH Ref.: Soderling, T.R., et al. 2001. J. Biol. Chem. 276, 3719. Chang, B.H., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 10890. Pereda, A.E., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13272. |
