4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione Pale yellow solid. A cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G2/M phase. Purity: ≥95% by TLC. RTECS UQ0492000, CAS 7689-03-4. Merck Index: 14, 1735
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R: 25-36/37/38-46; S: 22-26-36/37/39-45 |
