[2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline
SQ-14225 White to off-white solid. An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 ~320 nM). Purity: ≥98% by titration. RTECS UY0550000, CAS 62571-86-2. Merck Index: 14, 1774
Ref.: Uhal, B.D., et al. 1998. Am. J. Physiol. 275, L1013. Volpert, O.V., et al. 1996. J. Clin. Invest. 98, 671. Voors, A.A., et al. 1995. J. Cardiovasc. Risk 2, 413. Orning, L., et al. 1991. J. Biol. Chem. 266, 16507. Kostis, J. 1988. Am. Heart J. 116, 1591.
R: 63-43; S: 22-36 |
