Carbacyclic PGI2 White solid. Stable, synthetic, carbacyclic analog of prostacyclin with similar spectrum of activity but is only 10% as potent. Activates adenylate cyclase via G-protein coupled PGI2 receptors. Mimics effects of naturally-occurring prostacyclin. Purity: ≥98% by TLC. CAS 69552-46-1. Ref.: Ito, Y., et al. 1994. Atherosclerosis 110, 69. Sawai, T., et al. 1993. J. Biol. Chem. 268, 1995. Turner, J.T., et al. 1992. J. Pharmacol. Exp. Ther. 263, 708. Karim, S.M.M., et al. 1981. Prostaglandin Med. 6, 521. Aiken, J.W., et al. 1980. Prostaglandins 19, 629.
R: 20/21/22; S: 22-36 |
