2-Chloro-10-[3′-(dimethylamino)propyl]phenothiazine, HCl Off-white crystalline solid. HYGROSCOPIC. Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-a production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2. Purity: ≥99% by titration. Contaminants: Heavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%. RTECS SO1750000, CAS 69-09-0. Merck Index: 14, 2185
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R: 25-26-36/37/38; S: 22-26-36/37/39-45 |
