Lyophilized solid. A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca²⁺ transport and ATP hydrolysis by the sarcolemmal Ca²⁺/Mg²⁺-ATPase. Its action is strongly potentiated by phospholipase A₂. Inhibits protein kinase C (IC₅₀ = 1.8 µM). Purity: ≥95% by IEF. Contaminants: phospholipase A₂ activity: <2%. RTECS FH7482450.

Merck Index: 14, 1835
Ref.: Jang, J.Y., et al. 1997. Biochemistry 36, 4635. Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31. Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753. Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.
R: 20/21/22; S: 36
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