3-Amino-1H-pyrazolo[3,4-b]quinoxaline Red solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3b with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM). Purity: ≥95% by HPLC. CAS 40254-90-8. Ref.: Ortega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177. |