CK2 Inhibitor
TBB
TBBt
4,5,6,7-Tetrabromo-2-azabenzimidazole
4,5,6,7-Tetrabromobenzotriazole Colorless solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable benzotriazolo compound that acts as a higly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively) and DYRK (IC50 < 1 µM for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 µM, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). Purity: Single spot by TLC. CAS 17374-26-4. Ref.: Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645. Sarno, S., et al. 2003. Biochem. J. 374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129. Ruzzene, M., et al. 2002. Biochem. J. 364, 41. Sarno, S., et al. 2001. FEBS Lett. 496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418. |
