CK2 Inhibitor II, DMAT
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable brominated benzimidazolo compound that acts as a potent, high affinity and ATP-competitive inhibitor of CK2 (IC50 = 140 nM for rat liver CK2; Ki = 40 nM). Displays ~1300 fold greater selectivity over CK1 (IC50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No. 218697). Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1a) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Shown to induce apoptosis in Jurkat T cells at 2.5 µM. Purity: ≥95% by HPLC. CAS 749234-11-5. Ref.: Pagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040. |
