CKII Inhibitor, TBCA
(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Purity: ≥95% by HPLC. CAS 934358-00-6. Ref.: Pagano, M.A., et al. 2006. Chembiochem 8, 129 |
