Biotin-X-DEVD-FMK Brown solid. PROTECT FROM MOISTURE. Biotinylated derivative of Caspase-3 inhibitor II (Cat. No. 264155) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will enhance inhibitory activity in cell-free systems. Purity: ≥95% by TLC. Biotin-X-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-CH2F* (X = linker) Ref.: Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Nicholson, D.W., et al. 1995. Nature 376, 37. |
