Ac-LEVD-AFC White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. A fluorogenic substrate for caspase-4 (ICErel-II, TX, ICH-2). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also serves as a substrate for caspase-1. Purity: ≥95% by HPLC. Excitation max.: ~400 nm, Emission max.: ~505 nm Ac-Leu-Glu-Val-Asp-AFC Ref.: Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Lynch, T., et al. 1997. Mol. Psychiatr. 2, 227. Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907. |
