Calbiochem: 218759: Caspase-8 Inhibitor II

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��	Caspase-8 Inhibitor II

Cat. No. 218759��

All Categories � Calbiochem � Inhibitors � Apoptosis � Caspase

Granzyme B Inhibitor III
Z-IE(OMe)TD(OMe)-FMK

White powder. PROTECT FROM MOISTURE. A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. Purity: single spot by TLC.

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Ref.: Takizawa, T., et al. 1999. Microbiol. Immunol. 43, 245. Martin, D.A., et al. 1998. J. Biol. Chem. 273, 4345. Sweeney, E.A., et al. 1998. FEBS Lett. 425, 61. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

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250 �g Y N/A
1 mg Y N/A

Solubility Molecular Formula Mol. Wt.
DMSO� C₃₀H₄₃FN₄O₁₁� 654.7�

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218759: Caspase-8 Inhibitor II - English
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Related Categories:
All Categories � Calbiochem � Inhibitors � Apoptosis � Caspase

Selected Citations:
Sinead M. Miggin, et al. (2007) NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Procedings of the National Academy of Science 104, 3372-3377.
Kira Steigerwald, et al. (2005) The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Molecular Cancer Research 3, 78-89.
Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
Ashish K. Sharma and Baerbel Rohrer. (2004) Calcium-induced Calpain Mediates Apoptosis via Caspase-3 in a Mouse Photoreceptor Cell Line. Journal of Biological Chemistry 279, 35564-35572.
Wayne D. Thomas, et al. (2000) TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria. Journal of Immunology 165, 5612-5620.

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