Z-LE(OMe)HD(OMe)-FMK White to light brown solid. Supplied as a trifluoroacetate salt. PROTECT FROM MOISTURE. A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. Purity: single spot by TLC. Z-Leu-Glu(OMe)-His-Asp(OMe)-CH2F* Ref.: Fadeel, B., et al. 1999. Leukemia 13, 719. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. |
