Granzyme B Inhibitor II, Cell-permeable
IETD-CHO, Cell-permeable

White lyophilized solid. A potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide. Purity: ≥95% by HPLC.

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO

Ref.: Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Hamada, E., et al. 1990. J. Hepatol. 30, 807.