(1S,6S,7R,8aR)-Tetrahydroxyoctahydroindolizine Lyophilized solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. Plant alkaloid inhibitor of several b-glucosidases and a-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu3Man7-9(GlcNAc)2. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml. Purity: ≥98% by TLC. CAS 79831-76-8. Merck Index: 14, 1896
Ref.: Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267. Pili, R., et al. 1995. Cancer Res. 55, 2920. Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 8120. Pan, Y.T., et al. 1983. Biochemistry 22, 3975. Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.
R: 20/21/22; S: 36 |
