LEHD-CHO, Cell-permeable White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A potent, cell-permeable, and reversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide. Purity: ≥95% by HPLC. Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Leu-Glu-His-Asp-CHO Ref.: Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. |
