Ac-DNLD-CHO White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells. Purity: Single main spot with additional trace spot by TLC. Ac-Asp-Asn-Leu-Asp-CHO Ref.: Yoshimori, A., et al. 2004. BMC Pharmacol. 4, 7. |
