1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide
Inhibitor Boc-I
Z-L-NHNHCONHNH-LF-Boc Lyophilized white solid. PACKAGED UNDER INERT GAS. A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L. Purity: ≥95% by HPLC. Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z Ref.: Wang, D., et al. 2002. Biochemistry 41, 8849. |
