1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide
Inhibitor I
Z-L-NHNHCONHNH-LF-NH2 Lyophilized white solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. Purity: ≥97% by HPLC. H-Phe-Leu-NHNH-CO-NHNH-Leu-Z Ref.: Wang, D., et al. 2002. Biochemistry 41, 8849. |
