Liquid. In 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5. AVOID FREEZE/THAW CYCLES. Native cathepsin L from human liver. The most potent of the lysosomal proteinases, having a higher activity than cathepsins B and H in the degradation of a variety of physiological protein substrates. Cathepsin L is believed to be responsible for the generation of endostatin from NC1 domain in collagen XVII. One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5. Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. EC 3.4.22.15. Note: 1 mU = 1 milliunit.

Merck Index: 14, 1905
Ref.: Kurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857. Ferreras, M., et al. 2000. FEBS Lett. 486, 247. Baricos, W.H., et al. 1988. Biochem. J. 252, 301. McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.