CATI -1
Z-FG-NHO-Bz White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Call-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1). Purity: >90% by HPLC. Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C). Z-Phe-Gly-NHO-Bz Ref.: Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064. Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179. Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671. |
