Z-FG-NHO-BzME White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 6.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.1 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.3 x 104 M-1 sec-1), and papain (k2/Ki = 1.8 x 103 M-1 sec-1). Purity: >90% by HPLC. Half-life in buffered solution (pH 5-9) = 27 h (30°C); 300 h (0°C). Z-Phe-Gly-NHO-Bz-pMe Ref.: Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179. Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671. |
