Z-FY(OtBu)-COCHO Off-white solid. PACKAGED UNDER INERT GAS. A slow, tight-binding, and reversible inhibitor of human cathepsin L (Ki = 600 pM). Exhibits about 360-fold greater selectivity for cathepsin L compared to cathepsin B (Ki = 214 nM). Purity: single spot by TLC. Z-Phe-Tyr(OtBu)-COCHO • H2O Ref.: Lynas, J.F., et al. 2000. Bioorg. Med. Chem. Lett. 10, 1771. |