N4-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI
PNU 112455A White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. An aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). Binds to the ATP-binding pocket of Cdk2. Does not affect the activities of c-Met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase, and ERK2 at concentrations as high as 100 µM. Purity: ≥95% by HPLC. Ref.: Clare, P.M., et al. 2001. J. Biol. Chem. 276, 48292. |
