2-(3-Hydroxypropylamino)-6-(o-hydroxybenzylamino)-9-isopropylpurine Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition. Purity: ≥95% by HPLC. Ref.: Vermeulen, K., et al. 2002. Leukemia 16, 299. |