(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone
Locostatin
UIC-1005 White solid. PACKAGED UNDER INERT GAS. A cell-permeable N-(crotonyl)oxazolidinone compound that acts as a potent inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction. Shown to block eukaryotic cell migration (IC50 = 14 µM for inhibition of wound closure in MDCK cell monolayers) and decrease formation of lamellipodial protrusions at the wound margin. Also inhibits early development in frog embryos and tissue dynamics in embryonic explants. Displays no antibacterial activity. May serve as a useful tool for studying RKIP-mediated signaling pathways. Although locostatin is an irreversible inhibitor of RKIP, its cellular effects are generally reversible due to new biosynthesis. Purity: ≥98% by HPLC. CAS 133812-16-5. Ref.: Bement, W.M., et al. 2005. Chem. Biol. 12, 953. Zhu, S., et al. 2005. Chem. Biol. 12, 981. Mc Henry, K.T., et al. 2002. Chembiochem 3, 1105. |
