1,4-Dimethoxyacridine-9(10H)-thione Brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thioacridone compound that acts as a potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM). Purity: ≥95% by HPLC. CAS 141992-47-4. Ref.: Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279. |
