White to off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice. Purity: ≥98% by TLC. RTECS JR1670000, CAS 17397-89-6.

Merck Index: 14, 2004
Ref.: Loftus, T.M., et al. 2000. Science 288, 2379. Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90. Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
R: 20/21/22; S: 36