7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels. Purity: ≥98% by TLC. CAS 75450-34-9. Ref.: Jornot, L., et al. 1999. J. Cell Sci. 112, 1013. Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833. Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295. Griffiths, E.J., et al. 1997. Cell Calcium 21, 321. White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688. Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595. Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938. |
