Toyomycin

Yellow solid. PROTECT FROM LIGHT. Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA content and DNA base composition. Reversibly interacts with DNA in the presence of Mg²⁺. Binds to G:C pairs of helical DNA but does not intercalate. Purity: ≥90% by HPLC. Excitation max.: ~445 nm, Emission max.: ~575 nm RTECS GB7875000, CAS 7059-24-7.

Merck Index: 14, 2238
Ref.: Aich, P., et al. 1992. Biochemistry 31, 2988. Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 4913. Van Dilla, M.A., et al. 1983. Science 220, 620. Mizuno, K. 1963. J. Antibiot. 16, 22.
R: 26/27/28-61; S: 26-36/37/39-45