White solid. Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Purity: ≥98% by HPLC. RTECS MA4375000, CAS 66-81-9. Merck Index: 14, 2728
Ref.: Christner, C., et al. 1999. J. Med. Chem. 42, 3615. Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175. Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Cotter, T.G., et al. 1992. Anticancer Res. 12, 773. Takano, Y.S., et al. 1991. J. Pathol. 163, 329. Waring, P. 1990. J. Biol. Chem. 265, 14476.
R: 28-40-51/53-61; S: 45-53-61 |
