Shh Signaling Antagonist I

Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Purity: ≥95% by HPLC. RTECS GY0750000, CAS 4449-51-8.

Ref.: Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.