KAAD-Cyclopamine
3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
Shh Signaling Antagonist II Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Purity: ≥65% by HPLC. Ref.: Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005. |
