Daunomycin, HCl

Red crystalline solid. HYGROSCOPIC. Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerases I and II. Induces DNA single-strand breaks. Also induces apoptosis in HeLa S3 tumor cells. Purity: Potency: ≥840 µg/mg. RTECS HB7878000, CAS 23541-50-6.

Merck Index: 14, 2832
Ref.: Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105. Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072. Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375. Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27. Bellec, F., et al. 1992. Flow Cytometry 13, 880.
R: 22;