4,5-Dimethoxy-2-nitrobenzaldehyde
DMNB
DNA-Dependent Protein Kinase Inhibitor Bright Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities. Purity: ≥90% by GC. CAS 20357-25-9. Ref.: Willmore, E., et al. 2004. Blood,103, 4659. Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501. |
