2-Hydroxy-4-morpholin-4-yl-benzaldehyde
IC60211 Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A morpholino-salicylaldehyde compound that acts as a potent, selective and ATP-competitive inhibitor of DNA-PK (IC50 = 430 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC50 = 10 µM, 2.8 µM, 5.1 µM and 37 µM for a, b, d and g, respectively) and weakly inhibits a panel of several other kinases, including, ATM, CK2, GRK2, mTOR, PI 3KC2a, PI 3KC2b, PI 3KC2g and PI 4Kb, even at concentrations as high as 50 µM. Purity: ≥95% by HPLC. Ref.: Kashishian, A., et al. 2004. Mol. Cancer Ther. 2, 1257. Knight, Z.A., et al. 2004. Bioorg. Med. Chem. 12, 4749. Willmore, E., et al. 2004. Blood,103, 4659. |
