Bishydroxycoumarin
Dicumarol
3,3′-Methylenebis(4-hydroxycoumarin)

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by simultaneously blocking SAPK/JNK and NF-kB pathways. Does not affect phosphorylation of p38 or activation of AKT. Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC₅₀ = 180 µM and 150 µM, respectively). Purity: ≥98% by titration. RTECS GN7875000, CAS 66-76-2.

Merck Index: 14, 3090
Ref.: Seanor, K.L., et al. 2003. Antioxid. Redox. Signal 5, 103. Krause, D., et al. 2001. J. Biol. Chem. 276, 19244. Pink, J.J., et al. 2000. J. Biol. Chem. 275, 5416. Cross, J.V., et al. 1999. J. Biol. Chem. 274, 31150. Morrow, C.S., et al. 1998. J. Biol. Chem. 273, 20114. Weigert, R., et al. 1997. J. Biol. Chem. 272, 14200.
R: 22-48/25-51/53; S: 37-45-61