3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline Off-white solid. A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model. Purity: ≥90% by HPLC. CAS 129075-73-6. Ref.: Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089. Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137. Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107. R: 20/21/22; S: 36 |